Bute knocked out Mendy a few seconds before the end of the fourth round, with a left jab to the chin.
This was the 31-year old fighter's 29th professional victory. Bute's record includes 24 knockouts and no losses. Mendy has a record of 29 wins, including 16 knockouts.
Bute won the IBF super middleweight title in 2007, after defeating Alejandro Berrio.
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